Research Faculty | John Kerrigan | Hypothalamic Hamartoma (HH) Tissue Research Laboratory

John F. Kerrigan, MD, is the co-director of the Hypothalamic Hamartoma Program at Phoenix Children’s Hospital.  He attended college at the University of California, Berkeley, and earned his medical degree from the University of California, San Francisco, where he also completed his residency in the Department of Pediatrics. Dr. Kerrigan completed a pediatric neurology residency at the University of California at Los Angeles before coming to the Barrow Neurological Institute for a fellowship in clinical neurophysiology and epilepsy, under the direction of Robert S Fisher, MD, PhD. He is currently Associate professor of child health and neurology at the University of Arizona College of Medicine – Phoenix.

Dr. Kerrigan's clinical interests include seizure monitoring and surgical treatment for epilepsy. Dr. Kerrigan is the research director for the Hypothalamic Hamartoma (HH) Program, which includes multiple clinical and laboratory collaborators, examining treatment outcome and the basic cellular mechanisms responsible for seizure activity in HH tissue. 

He is the principal investigator in the Hypothalamic Hamartoma Tissue Research Laboratory, which is utilizing confocal microscopy with intracellular labeling and immunohistochemistry to study the microanatomy of HH tissue.  He is an author or co-author of over 50 papers for peer-reviewed publication. 

Project:  The Hypothalamic Hamartoma (HH) Tissue Research Laboratory focuses on the study of surgically-resected HH with the aim of understanding the basic cellular mechanisms responsible for seizure activity arising from this human epileptic tissue.  HH are congenital, benign tumors located in the ventral hypothalamus, and are responsible for treatment-resistant epilepsy and other related neurobehavioral symptoms. 

Our lab utilizes traditional neuroanatomical techniques to study HH, including immunohistochemistry, stereology, Golgi staining, and confocal imaging of micro-injected neurons. We work in collaboration with other research laboratories at Barrow and elsewhere that utilize complementary research platforms, including cellular electrophysiology.

Publications

Funding Sources: 

Extramural:  Arizona Biomedical Research Commission (ABRC)

Intramural:  Barrow Neurological Foundation (BNF)

 

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